Redefining chronic endometritis: the importance of endometrial stromal changes

ObjectiveTo develop diagnostic criteria for chronic endometritis and compare the prevalence of between women with recurrent pregnancy loss (RPL) controls.DesignCohort study.SettingSingle academic fertility center.PatientsWomen unexplained RPL (two or more losses) prospectively recruited controls without a history infertility.InterventionsEndometrial samples were stained hematoxylin eosin CD138. A pathologist blinded to patient recorded number plasma cells per 10 high-power fields (HPFs). In addition, presence absence endometrial stromal changes was documented.Main Outcome MeasurePrevalence endometritis.ResultsEndometrial from 50 26 evaluated. When defined as one HPFs, 31% 56% met criterion. both required diagnosis endometritis, no 30% criteria.ConclusionsAlthough rare found in biopsy controls, limited cohort. We propose that be HPFs setting changes. With use these strict criteria, have significantly higher rate supporting an association RPL. To controls. Cohort study. Single center. Women infertility. Endometrial documented. Prevalence endometritis. criteria. Although